Category: Science
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The toxin in the garden: The Wilms tumor miracle
Prasad IyerSingapore The history of modern oncology almost always begins with a single name and clinical obsession: Sidney Farber and his war against “the white blood.” The 1947 aminopterin breakthrough at Boston Children’s Hospital is recounted with the reverence of a foundational story, the moment the tide first turned against pediatric leukemia. Yet, in the…
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Paul Janssen: Fentanyl innovator
Alan Jay SchwartzPhiladelphia, Pennsylvania, United States Fentanyl is a remarkably potent opioid analgesic, but unfortunately is easily abused. It was invented by Paul Janssen (1926–2003) a Belgian entrepreneurial physician and founder of Janssen Pharmaceutica.1,2 Paul was the son of Constant Janssen (1895–1970), whose entrepreneurial mission importing and marketing pharmaceuticals eventually eclipsed his physician general practice.…
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A wartime disaster that led to a cure in oncology
Prasad IyerSingapore In the harbor of Bari on the night of December 2, 1943, the German Luftwaffe punctured the Italian coastline with fire and hit the SS John Harvey, a ship secretly carrying two thousand mustard gas bombs. A toxic soup of fuel oil and chemical agents blanketed the water and clung to the skin…
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The guinea pig’s gift: Serendipity and the starvation of leukemia
Prasad IyerSingapore Medical breakthroughs often arrive not with a fanfare of logic, but with the quiet, baffling persistence of a laboratory anomaly that refuses to be ignored. In 1953, the laboratories of Cornell University Medical College operated in a world away from the high-stakes precision of modern oncology. Dr. John Kidd was not hunting for…
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Stem cells and their promise in treating disease
Ashok SinghChicago, Illinois, United States Stem cells represent a fascinating and promising frontier in modern medicine. As they multiply, stem cells are unique in their ability to differentiate themselves into cells with different properties. This ability is observable in the development of a complete body from a single, unique fertilized cell. After fertilization and multiplication…
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A second mind in scientific writing
Rao UppuBaton Rouge, Louisiana, United States Clarity in scientific writing is a rare achievement. As Margaret Thatcher would have said in a different context, it does not fall from Heaven but needs work, often a lot of it. I learned this years ago, not in a laboratory or a seminar, but in my living room,…
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Martinus van Marum, physician, scientist, and inventor
Annabelle SlingerlandLeiden, Netherlands Martinus van Marum, who was born in 1750 during the era of the Republic of the Seven United Netherlands, went on to enjoy a remarkable career in science. His father, Petrus van Marum, was a graduate engineer from Groningen who had started a pottery-factory in Delft, married Cornelia van Oudheusden, and had…
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The chemistry of coffee and the paradox of balance
Rao UppuBaton Rouge, Louisiana, United States Coffee is more than a daily stimulant; it is a quiet lesson in biological balance. The long-running debate over whether coffee is “good” or “bad” increasingly shows that, for most people, moderate intake—about one to three cups a day—sits comfortably within that balance. Coffee also carries cultural meaning, reminding…
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In praise of speleology
As freshmen at the university, we were advised to join a society or club in order to expand our horizons through what later became known as a liberal education. So, my classmate Pete convinced me to join the speleological society and suggested we should explore the Jenolan Caves, a major tourist attraction in New South…
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Carl Linnaeus as dietitian and pediatrician
Göran WettrellLund, Sweden Carl Linnaeus as pediatrician Carl Linnaeus is best known as a botanist through his classification of the sexual system of plants and taxonomy. His interest in botany was noticed from a young age at Växjö Gymnasium by his teacher, provincial physician Johan Rothman, who instructed the young student in botany and medicine.…