Tag: Vignette
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The tenuous gut-brain axis and its role in schizophrenia
When the son of the American surgeon Bayard Holmes developed schizophrenia, Holmes devoted his life to researching the disease. In 1916, impressed by the new germ theory that stated many diseases were caused by an overgrowth of bacteria, he tried to cure his son by opening his abdomen and going through the appendix to wash…
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St. John’s wort: Repelling witches and treating depression
Even the most devout Christian might be excused for not taking off time from his work or pleasures to celebrate on June 25 the birthday (not the gruesome beheading) of St. John the Baptist. This is also the day of the summer solstice (the longest day of the year) when the beautiful yellow St John’s…
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Shaggy dog licks patient
As a very young doctor, a very long time ago, I had to support myself by making house calls as a locum or for an agency. The calls often came at night, often from a worried-well patient. Finding the right house was frequently challenging, especially in the suburbs, where people used fancy, elegant names instead…
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Kuru, the laughing disease of New Guinea
New Guinea is the second-largest island in the world that is not a continent (after Greenland). It is divided into the Republic of Papua-New Guinea in the east and a western area that belongs to Indonesia. In both parts, indigenous populations face significant health challenges because of poverty, parasitic diseases, and poor medical facilities. Of…
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Nicholas Cusanus
Avi OhryTel Aviv, Israel Non-medical scientists and scholars often contribute substantially to medicine. Nicolaus Cusanus (1401–1464), also known as Nicholas of Cusa and Nikolaus Krebs von Kues, was a German cardinal of the Roman Catholic Church, philosopher, jurist, mathematician, and astronomer. In Padua he earned a doctorate in canon law in 1423. He became a…
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Dr. Mary Edwards Walker: A trailblazer for female surgeons
Shabnam ParsaLeshya BokkaLiam ButchartStony Brook, New York, United States Dr. Mary Edwards Walker (1832–1919) was the first female surgeon in the United States—a pioneering educator, clinician, and medical innovator.1 Her academic path was paved by her parents’ dedication to education. Vesta and Alva Walker established the first free school in Oswego, New York, where they…
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Chocolate created a commotion in Chiapa cathedral
Howard FischerUppsala, Sweden “Beware the chocolate of Chiapas.”—Mexican saying The cacao bean, the essential ingredient in chocolate, is native to Southern Mexico, Central America, and South America. There is evidence that chocolate was used in Ecuador over 5,000 years ago.1 The Aztecs produced a ceremonial drink called chocolatl. The Spanish invaders of the New World…
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Sand flies, leishmaniasis, and kala-azar
Sand flies are about three millimeters long and gray, brownish or golden, with long, piercing mouthparts adapted for sucking blood from their hosts. These seemingly innocuous creatures, classified as belonging to the genus Phlebotomus or Lutzomyia, have long legs and hairy wings held in a vertical V-shape when at rest. They seek moist resting places…
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Fasciola hepatica, the liver fluke of sheep and cattle
The liver flukes Fasciola hepatica and gigantica are parasitic infections that affect humans and animals—cattle, sheep, and goats—in all inhabited areas where they are raised, on all continents, and in over eighty countries. People acquire the disease by eating raw vegetables such as watercress that have been contaminated by one of thirty species of snails,…
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Tapeworm tribulations
Taenia saginata, solium, and asiatica are three related species of tapeworms, each with its own lifecycle, mode of transmission, and clinical implications. The adult tapeworms cause few symptoms, but their larvae can be more troublesome. These parasites have afflicted mankind for thousands of years, perhaps when switching from large carnivores to less dangerous hosts such…