Category: Cardiology
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From bedside to bench: The discovery of calmodulinopathy
Göran WettrellLund, Sweden As a pediatrician specializing in pediatric cardiology, I met in 1982 a twelve-year-old-boy with syncope when playing football. He had four previous episode of losing consciousness during physical activity and once during a fire alarm. His resting ECG was normal but his long-term ECG registration revealed exercised-induced ventricular extrasystoles of increasing complexity.…
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Sunao Tawara
Sunao Tawara was a prominent Japanese pathologist and anatomist best known for discovering in 1906 the atrioventricular node, also known as the AV node or bundle of Tawara. This small mass of specialized cardiac muscle fibers located between the atria and ventricles of the heart is a key component of the heart’s conduction system, responsible…
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Rene Favaloro—Father of cardiac bypass surgery
Arpan K. BanerjeeSolihull, England Over the last century, there have been many important contributions to medicine made by Argentinians. Of these Rene Geronimo Favaloro’s must surely be of the greatest, and his work on cardiac bypass surgery has saved countless of lives. Born of Sicilian ancestry on July 12, 1923, in La Plata, Argentina, Favaloro…
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Two giants in thoracic surgery: Clarence Crafoord and Åke Senning
Göran WettrellLund University, Sweden Clarence Crafoord Clarence Crafoord (1899–1984) was one of the most outstanding surgeons in Sweden during the twentieth century (Figure 1). He started his surgical training in the early 1920s. Postoperative complications such as obstructing pulmonary thrombosis were a frequent cause of death. In 1927, Crafoord performed two successful acute pulmonary embolectomies.1…
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Jean-Baptiste de Sénac and his early textbook on cardiology
Göran WettrellLund, Sweden William Harvey was an important figure in the early days of cardiovascular physiology. Based on meticulous observations, he published De Motu Cordis and Sanguinus in 1628 and has been proposed as the founder of physiology and cardiology.1 During the late seventeenth and early eighteenth centuries, physicians such as Raymond Vieussens (1641-1715), Giovanni-Maria…
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Heart to heart
Frank BucharHamilton, Ontario, Canada I had a heart attack on Valentine’s Day. What are the chances? Later, when I thought about the funny parts, like the undershorts I happened to be wearing, it struck me that you can find humor, like tragedy or farce, anywhere if you choose to, if you attend closely enough. My…
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Remembering Sir Thomas Lewis’ contribution to understanding heart failure
Daniel GelfmanIndianapolis, Indiana, United States Sir Thomas Lewis (1881–1945) has been called one of the “fathers of modern cardiology” due to his many significant contributions to that discipline. In 1930 he wrote a landmark paper clarifying the disease “congestive (heart) failure,” revealing clues that are present in the jugular veins, for making the diagnosis and…
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The importance of the “The David Sign”
Daniel M. GelfmanThad E. WilsonIndianapolis, Indiana, United States A recent article in JAMA Cardiology titled “The David Sign” discussed the presence of “persistent” external jugular venous distention “hiding in plain sight” on one of the world’s most famous statues: Michelangelo’s David, completed in 15041 (Figure 1). David is shown just before his fight with the…
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Richard J. Bing: Reflecting on a century of creativity and innovation
Joseph BurnsYehuda ShapirNew Hyde Park, New York, United States As the tenth anniversary of the passing of Dr. Richard J. Bing approaches, the occasion offers an opportune moment to reflect on the life and momentous achievements of an eminent cardiologist. Richard J. Bing was born in Nuremberg, Germany on October 12, 1909.1 His father was…
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William Harvey before King Charles I
In 1628 William Harvey published his classic work De Motu Cordis (Of the Motion of the Heart and Blood in Animals) demonstrating that the blood passed from the left ventricle to the capillaries at the periphery and back through the veins to the right side of the heart. He received many honors for his work, and…