Tag Archives: DNA

Gain of function

July 7, 2022

Jayant Radhakrishnan Darien, Illinois, United States   “It is no good to try to stop knowledge from going forward. Ignorance is never better than knowledge.” – Enrico Fermi (1901–1954)   SARS-CoV-2 virus anatomy with proteins labeled. Created by Maya Peters Kostman for the Innovative Genomics Institute. CC BY-NC-SA 4.0. “Gain of Function” (GoF) burst into […]

The mystique of psychiatry: a closer look

March 31, 2022

Lawrence Climo Lincoln, Massachusetts, United States   Photo by Larry Ayalo on Unsplash As a retired psychiatrist, I have been thinking about the mystique that surrounds our profession. Psychiatrists seem to trigger three provocative associations that set them apart from other physicians. The first, sometimes interpreted as a wish, is that psychiatrists read minds and therefore […]

A note on handedness

October 15, 2021

JMS Pearce Hull, England, United Kingdom   Handedness (chirality) refers to the preferential use of one hand over the other. It is a matter of degree; it is seldom absolute. Population left and right preference existed in the Neanderthals (lived from 400,000 to about 40,000 years ago) onwards. Only homo sapiens amongst the great apes […]

Trijntje Keever—a tall tale

September 30, 2021

Orit Pinhas-Hamiel Hamiel Uri Tirosh Amit Ramat Gan, Israel   A life-size painting of Trijntje Keever. Unknown Painter. 1633. Via Wikimedia. There is a life-size painting in the city of Edam in The Netherlands that portrays a girl who is exceptionally tall with disproportionately long hands. The artist is unknown, but the name of the […]

Review: The History of the World in 100 pandemics, plagues and epidemics

September 24, 2021

Arpan Banerjee Solihull, United Kingdom   Cover: The History of the World in 100 pandemics, plagues and epidemics. The publication of this book could not have been better timed. The book sets out to show how pandemics, epidemics, and infectious diseases have shaped human history over the last 5,000 years. Its contents help us place […]

A look back at insulin

August 24, 2021

Shrestha Saraf Sutton Coldfield, United Kingdom Sanjay Saraf Sudarshan Ramachandran Birmingham, United Kingdom   Sir Frederick Banting and Dr. Charles Best co-discoverers of Insulin. Library and Archives Canada. Via Wikimedia. As we approach the centenary of the isolation, purification, and clinical use of insulin, it is an appropriate moment to reflect on the impact of […]

Painting an ICU

August 19, 2021

Mark Tan Northwest Deanery, England, United Kingdom   Claude Monet’s Japanese Bridge and Water Lilies from 1899. Princeton University Art Museum. Wikipedia. “[Monet was] only an eye – yet what an eye.” — Paul Cézanne   Much has been written about Claude Monet’s ophthalmic pathology.1-4 However, attributing his stylistic development to cataracts alone seems an […]

Mitochondrial DNA: a maternal gift

April 26, 2021

Marshall Lichtman Rochester, New York, United States   Human haplogroup tree rooted at Mitochondrial Eve. By Wapondaponda. 2009. Via Wikimedia. CC BY-SA 3.0 DNA is arrayed on twenty-three pairs of chromosomes in human cell nuclei. It is coiled tightly around proteins called histones that together with DNA form a chromosome. The largest chromosome carries several […]

Ancient Greek plague and coronavirus

March 26, 2021

Patrick Bell Belfast, Northern Ireland   Plague in an Ancient City by Michael Sweerts, ca 1650. Credit Los Angeles County Museum of Art. Introduction Homer’s Iliad, Sophocles’ Oedipus the King, and Thucydides’ History of the Peloponnesian War have been termed “the three earliest, and arguably most influential, representations of the plague in Western narrative.”1 This […]

The first description of DNA: a six million dollar letter from Francis to Michael Crick

August 4, 2020

Marshall A. Lichtman  Rochester, New York, United States   Figure 1. The boyish appearing James Watson (left) and the Francis Crick with their three-dimensional model of DNA in their Cavendish Laboratory office at Cambridge University, United Kingdom. Circa 1953. Photo credit: A. Barrington Brown/Science Photo Library. Via the Rockefeller University Digital Commons. In the April […]