Tag: Science
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The myth of knowledge
Chloe LeeSingapore Legend has it that aeons ago on the Island of Colchis hung a magical Golden Fleece that could heal any disease. Modern medicine has proposed a new explanation for this incredible tale: Colchicum autumnale, a flowering plant now used to produce colchicine. Since Grecian antiquity, its therapeutic properties have been widely acknowledged, and…
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Robert Hooke and Micrographia
JMS PearceHull, England It is perhaps rash to attempt to appraise the work of Robert Hooke (1635–1703), but renewed attention is merited to a great scientist whose contribution to medicine and science has not been adequately acknowledged. Robert Hooke was a scientist and biologist who, at a time when science was young and not yet…
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Keeping corpses company
Nater AkpenMakurdi, Benue State, Nigeria Inspired by an error where he had misjudged the time since death—not by hours or days—by 112 years,1 William Bass set up the Anthropological Research Facility in Tennessee. His request to his dean was simple: Give me some land to put dead bodies on. His research facility, colloquially called the…
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Fraudulent medical research and “zombie articles”
Howard FischerUppsala, Sweden “Ninety percent of everything is crap.”– Sturgeon’s law1“Garbage in, garbage out.” – Early computer-speak for “nonsense input produces nonsense output” The publishing of studies in medical journals is based on trust. When journal editors receive a manuscript, they first look at the title to determine if the subject may be appropriate for…
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Christopher Wren’s contributions to medicine
JMS PearceHull, England An extraordinary natural philosopher and Renaissance man, Christopher Wren (1632–1723) (Fig 1) was primarily an astronomer and architect.1 He is remembered mostly for his work after the Great Fire of London of 1666 as designer of St. Paul’s Cathedral, originally erected in AD 604. Wren laid the first stone at on Ludgate…
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A note on circadian clocks
JMS PearceHull, England I first started to enquire about circadian rhythms when wondering what it was that caused the periodicity of migraines in relationship to such diverse factors as emotions, tiredness, relaxation, hormonal changes, bright lights, and noise.1 The periodic threshold appeared susceptible to hypothalamic function, which in turn was modulated by seasonal patterns and…
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From silks to science: The history of hematoxylin and eosin staining
Vidhi NaikAberdeen, Scotland Introduction Hematoxylin and eosin, dyes used to stain tissue samples, collectively known as H&E, form the benchmark for histological stains. These dyes possess a profound and alluring history, which includes stories of the fabric industry, pirates, fine art, and eventually histology. The development of hematoxylin The origins of hematoxylin can be traced…
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Help from the horseshoe crab
Howard FischerUppsala, Sweden The horseshoe crab (Limulus polyphemus) has not changed in more than 450 million years. It has been called “a living fossil.”1 It is, in fact, not a crab at all, but an arthropod, more closely related to arachnids such as spiders and scorpions. It is found on the eastern coast of North…
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The origins of NIH medical research grants
Edward TaborBethesda, MD, United States The US National Institutes of Health (NIH) supports medical research in non-government universities and hospitals and some small businesses. The cost and scope of these grants significantly exceed those of NIH’s own intramural program of clinics, wards, and laboratories. The NIH extramural grants today provide more than $37 billion1,2 for…