Tag: inoculation
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“God Helps Them That Help Themselves”: Poor Richard and the inoculation controversy
Stewart JustmanMissoula, Montana, United States Before vaccination there was inoculation, and long before opposition to vaccination for Covid-19 there was furious resistance to the practice of inoculating for smallpox. Upon being introduced into Boston in 1721, in the midst of an outbreak of smallpox—exactly the wrong time and place for a dispassionate trial of a…
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Mortality data, risk probability, and the psychology of assent in the enlightenment smallpox debate
David SpadaforaPinehurst, North Carolina The present health crisis is hardly the first to provoke significant controversy about preventing and treating widespread disease. Debate over epidemic-related data, its reliability, and its uses has a long history. So does concern about the psychological elements involved in securing assent from physicians and an endangered population for the use…
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The global journey of variolation
Mariel TishmaChicago, Illinois, United States Humanity has eliminated only one infectious disease—smallpox. Smallpox is a very old disease and efforts to prevent it are almost as old. They included a technique called variolation, also known as inoculation or engrafting, in which individuals were infected with live smallpox virus to produce a milder form of the…
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Lady Mary Wortley Montagu and smallpox
JMS PearceHull, England There are few examples of people with no medical training who independently make significant advances in medical practice. One such person was the elegant, aristocratic Lady Mary Wortley Montagu (1689–1762)—daughter of Evelyn Pierrepont, first Duke of Kingston-upon-Hull—whose portrait is in the splendid Library Room at Sandon Hall, Staffordshire. It was painted in…
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Vaccinating a young child
The entire household has assembled to watch a child being vaccinated against smallpox. Inoculation with material derived from cowpox lesions was still sufficiently novel to excite such interest. It had been first attempted in 1796 by Edward Jenner, who used the term vaccination because the Latin for cow is vacca and cowpox was called vaccinia.…
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George Bernard Shaw’s The Doctor’s Dilemma
In the first act of Shaw’s play, several doctors come to congratulate Sir Colenso Ridgeon, recently knighted for discovering that white blood cells will not eat invading microbes unless they are rendered appetizing by being nicely buttered with opsonins. Patients supposedly manufacture these opsonins on and off, and would be cured if inoculated when their…
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Washington’s deadliest enemy
Kathryn ToneWiesbaden, Germany As Commander of the Continental Army, General George Washington is famously remembered for the surprise 1776 Christmas attack on the Hessian garrison in Trenton, New Jersey. A bold, relatively spontaneous decision, the attack was a last-ditch effort to salvage some sort of victory after some punishing eight months of humiliating defeats from…