Tag: Claude Bernard
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Silas Weir Mitchell and causalgia
JMS Pearce Hull, England, United Kingdom Fig 1. Silas Weir Mitchell. Photo by Frederick Gutekunst, 1881. National Library of Medicine. Via Wikimedia. Public domain. Silas Weir Mitchell (1829 – 1914) (Fig 1) was born in Philadelphia, the seventh physician in three generations. Webb Haymaker gives an early clue to his unconventional personality when he…
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Head and hand: Claude Bernard’s experimental medicine
James A. Marcum Waco, Texas, United States Claude Bernard. Source: National Library of Medicine, the hisotry of medicine public domain image files. Claude Bernard’s Introduction à l’étude de la médecine expérimentale, originally published in 1865, occupies a critical position in the development of experimental medicine and science.1 In the introduction to the book, Bernard…
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A look back at insulin
Shrestha Saraf Sutton Coldfield, United Kingdom Sanjay Saraf Sudarshan Ramachandran Birmingham, United Kingdom Sir Frederick Banting and Dr. Charles Best co-discoverers of Insulin. Library and Archives Canada. Via Wikimedia. As we approach the centenary of the isolation, purification, and clinical use of insulin, it is an appropriate moment to reflect on the impact of…
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Claude Bernard, one of the greatest scientists
Claude Bernard (1813 –1878), “one of the greatest of all men of science,” originated the term milieu intérieur, and furthered the concept of homeostasis. After an early high school and college education, he become an assistant in a druggist’s shop and contemplated becoming a writer, but was persuaded to study medicine and became an intern at the Hôtel-Dieu hospital…
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A changing paradigm for medical research: the evolution of the clinical trial
Kayvon Modjarrad Bethesda, Maryland, United States This history of science follows a convoluted path of imperceptible intellectual drifts and sudden philosophical shifts. Scientific milestones are, therefore, the result of gradually building thought processes. This is as true for advances in the methods of scientific inquiry as it is for the content of scientific discovery.…
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Cournand and Richards: Pioneers in cardiopulmonary physiology
Philip R. LiebsonChicago, Illinois, United States During World War I among the allied forces were an artillery lieutenant just out of college and a medical student who acted as an auxiliary battle surgeon because of the high mortality among battalion surgeons. They were, respectively, Dickinson W. Richards, Jr. (1895—1973) and Andre Cournand (1895—1988). Eventually they…