Hektoen International

A Journal of Medical Humanities

Armenia: History, culture, and medicine

The modern Republic of Armenia is a small country in Transcaucasia that offers stunning mountain and valley views. From its capital, Yerevan, one can see Mount Ararat, now considered to be in Turkey, located only about twenty miles from the border between Armenia and Turkey. Mount Ararat is historically, culturally, and symbolically important to Armenians.

Modern Armenia occupies less than 10% of its earlier historical lands. The rest lies in Turkey, Azerbaijan, Georgia, the Soviet Union, and extends even into parts of Syria, Lebanon, and Iraq. Armenia’s current population is about 3 million, but the Armenian diaspora numbers about 5 to 8 million people, living mainly in Russia, the United States (California, Massachusetts, Michigan), France, Georgia, Lebanon, Iran, and Syria. They tend to regard themselves as Armenians, but many do not speak Armenian and are often well assimilated into their country of residence.

Armenia’s history stretches back thousands of years, to about 9000 BCE, and to various ancient cultures and populations. Between the 9th and 6th centuries BCE, the ancient kingdom of Urartu, in what is now eastern Turkey around Lake Van, built massive fortresses, developed cuneiform scripts, and founded Yerevan (the Erebuni fortress) in 782 BCE, about 28 years before the foundation of Rome. Urartu eventually clashed with Assyria. In 714 BCE, the Assyrian King Sargon II defeated the Urartu forces, beginning its eventual downfall.

By roughly 600 BCE, the Kingdom of Urartu had vanished and had largely become a satrapy of the Achaemenid Persian Empire. In 331 BCE, Alexander the Great absorbed most of Armenia into his Macedonian empire, but local rulers retained substantial autonomy. Around 189 BCE, a general named Artaxias I rebelled against the Seleucid successors of Alexander and founded the Artaxiad Dynasty, an indigenous Armenian family. This dynasty produced Armenia’s most famous king, Tigranes II the Great (r. 95–55 BC), who briefly ruled from the Caspian Sea to the Mediterranean.

In 12 CE, during their reign over Asia Minor, the Romans overthrew the Artaxiad Dynasty. Armenia became a buffer between the Roman and Parthian Empires, with ethnic Parthians ruling as Arsacid princes from 54 CE to 428 CE. In 301 CE, the Arsacid King Tiridates III and Saint Gregory the Illuminator proclaimed Christianity the state religion, making Armenia the world’s first Christian nation. In 405 CE, Mesrop Mashtots invented the Armenian alphabet, which preserved Armenian national identity through centuries of foreign rule. But in 387 CE, the Byzantine Empire and the Sasanian Persian Empire partitioned Armenia and, in 428, abolished the local Arsacid monarchy. In the mid-7th century, the expanding Arab Caliphate took control of Armenia.

In 885, Ashot I of the Bagratuni dynasty re-established an independent Armenian kingdom that ruled Armenia until 1045, when repeated invasions by the Byzantine Empire and Seljuk Turks led to the Bagratid kingdom’s collapse. Some Armenian refugees migrated to the Mediterranean coast and established the Armenian Kingdom of Cilicia around 1080 (crowned a kingdom in 1198). Cilicia served as a vital Christian ally of the European Crusaders. It fell to the Mamluks of Egypt in 1375.

After the 16th century, the Islamic empires divided Armenia between themselves. The Ottomans controlled Western Armenia, while the Iranian Safavids ruled the East. During the Ottoman-Safavid War of 1604–1605, Shah Abbas I forcibly relocated about 150,000 to 300,000 Armenians from Eastern Armenia’s borderlands to his new Safavid capital, Isfahan, in central Persia. This massive migration, part of a scorched-earth policy in the war against the Ottomans, had profound economic and cultural consequences for the Armenian people.

In 1828, Russia conquered Eastern Armenia from Persia and incorporated it into its empire. The rest of Armenia remained part of the Ottoman empire. About a century later, during World War I, the Ottoman Empire subjected its Armenian population to systematic massacres and deportation (1915), killing an estimated 1.5 million people. A short-lived independent Armenian state existed from 1918 to 1920, before the Soviet Union absorbed the entire country. Armenia did not regain independence until the Soviet Union dissolved in 1991.

Armenia has a long medical tradition. Early Christian monasteries ran hospices and infirmaries that cared for the sick and travelers. Anania Shirakatsi, a 7th-century polymath, wrote on mathematics and cosmography and also left a body of practical natural science. In the 12th century, Mkhitar Heratsi, a physician in Cilician Armenia after whom Yerevan’s medical university is named, wrote an influential work on fevers. He wrote Consolation for Fevers, drawing on Greek, Arabic, and local medical knowledge, and is regarded as the first major medical author in Armenian. Another major figure was the 15th-century physician Amirdovlat Amasiatsi. His writings dealt extensively with medicinal plants, minerals, and animal-derived substances. Many Armenian medical manuscripts survive in Yerevan’s great manuscript repository. At the household level, Armenian culture is famous for its food and hospitality. Lavash, a bread traditionally baked in a clay oven, is tasty and nourishing. Its preparation passes skills across generations and brings people together around a necessity.

Armenia became a Soviet republic in 1920, and its healthcare expanded considerably. Yerevan State Medical University, founded in 1920, trained generations of physicians, and the Soviet state built a centralized network of hospitals and clinics offering universal access. Armenian scientists have made significant contributions to cardiology, surgery, and physiology.

Contemporary Armenian healthcare has strengths but also persistent difficulties. Childhood vaccination rates are high and infant and maternal mortality are declining, but financial barriers to care remain, and health workers are overly concentrated in the capital. Chronic diseases now dominate the burden of illness, making hypertension, smoking, and unhealthy diet the principal risks. The country’s response to COVID-19 illustrates Armenia’s resilience, as does the conflict over Nagorno-Karabakh, which saw more than 100,000 refugees arrive in Armenia within one week in September 2023 and required an urgent response and ongoing support.

Thus, Armenian history is one of persistent endurance. A small nation surrounded by large empires has preserved its language, religion, and culture despite foreign conquest, dispersal, and genocide. Its past shows an extraordinary resilience and capacity to recover from catastrophic emergencies and crises.


GEORGE DUNEA, MD, Editor-in-Chief

Fall 2026

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