Tag Archives: Vincent Allfrey

Histone acetylation a half century later: the modest birth of epigenetics

Beatriz GT Pogo   This figure (from Pogo et al 1966) shows the time course experiment comparing incorporation of acetyl groups into histones and uridine into RNA. It can be seen that acetylation took place before RNA synthesis suggesting that changes in the interaction between histones in DNA preceded gene activity. In 1964 I joined […]