Tag: LQTS
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From bedside to bench: The discovery of calmodulinopathy
Göran WettrellLund, Sweden As a pediatrician specializing in pediatric cardiology, I met in 1982 a twelve-year-old-boy with syncope when playing football. He had four previous episode of losing consciousness during physical activity and once during a fire alarm. His resting ECG was normal but his long-term ECG registration revealed exercised-induced ventricular extrasystoles of increasing complexity.…
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Early clinical and molecular discoveries in Long QT Syndrome
Göran WettrellSweden Sudden and unexpected death in people who are less than thirty-five years of age is associated with negative autopsy results in forty percent of cases.1 Long QT Syndrome (LQTS) is one of the most common cardiac ion channelopathies to cause sudden death in young people. In the late 1950s and early 1960s, reports…