Tag: Jay McLean
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The discovery of heparin
Mostafa ElbabaDoha, Qatar The sulfated glycosaminoglycan known as heparin is the most common anticoagulant used in clinical medicine. Its therapeutic role is to increase antithrombin activity. While its physiologic role in humans is not fully understood, heparin is stored and secreted from mast cells at sites of tissue injury and is believed to provide local…
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The early history of anticoagulants: 1915–1948
Philip R. LiebsonChicago, Illinois, United States Dedicated to the memories of Irving S. Wright and Stephen S. Scheidt, former colleagues at the New York Hospital-Cornell University Medical Center. Much of the background for this essay was provided by the Mueller-Scheidt Special Report, to which I am grateful.1 Steve Scheidt was a colleague of mine at…